The game serves as a filler for all the series' major events, and Wesker is playable throughout three missions, including Russia, the Research Facility from the prequel, and the Spencer Estate.
You also get to play as Chris and Jill, as they attempt to defeat the Umbrella monsters in a snowy region of Russia (which is also the base of operations of the new antagonist, Sergei Vladimir). Ada Wong is playable in her own mission, which has her in pursuit of another G-Virus sample.
Furthermore, Richard Aiken IS playable for the first time ever, alongside Rebecca Chambers, in a scenario which depicts how he got bitten by Yawn the snake inside the attic.
